Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids
نویسندگان
چکیده
منابع مشابه
Exploiting protected maleimides to modify oligonucleotides, peptides and peptide nucleic acids.
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids, peptides and peptoids, making use of standard solid-phase procedures. Maleimide deprotection takes place upon heating, which can be followed by...
متن کاملProtected maleimide building blocks for the decoration of peptides, peptoids, and peptide nucleic acids.
Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers. Suitable maleimide deprotection conditions were established in each case. The stability of the adducts generated by Michael-type maleimide-thiol reaction and Diels-Alder cycloaddition to ma...
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We treat theoretically the problem of the specificity of interaction between nucleic acid and an oligonucleotide, its analog or its mimic (such as peptide nucleic acid, or PNA). We consider simplest models with only essential details using numerical solutions of kinetic equations and the kinetic Monte Carlo method. In our first model, describing the formation of complementary duplex, we demonst...
متن کاملSection 8.2 - Labeling Oligonucleotides and Nucleic Acids
Cat # Product Name Unit Size S-7563 SYBR Green I nucleic acid gel stain *10,000X concentrate in DMSO* ............................................................................................................... 500 μL S-7567 SYBR Green I nucleic acid gel stain *10,000X concentrate in DMSO* ..........................................................................................................
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Cyclohexenyl nucleic acid (CeNA) is a nucleic acid mimic, where the (deoxy)ribose sugar has been replaced by cyclohexenyl moieties. In order to study the conformation of cyclohexenyl nucleosides by NMR, the HexRot program was developed to calculate conformations from scalar coupling constants of cyclohexenyl compounds, analogous to the methods applied for (deoxy)ribose nucleosides. The conforma...
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ژورنال
عنوان ژورنال: Molecules
سال: 2015
ISSN: 1420-3049
DOI: 10.3390/molecules20046389